Science

The Mitochondria

Powerhouse to Cells

Innovative small molecule drug discovery for targeting aging and age-related diseases.

We have discovered a series of potent molecules that extend lifespan and enhance mitochondrial health by inducing mitophagy. These compounds may have a significant role on disease and aging.

Mitochondria, known as the cell’s ‘powerhouse,’ produce ATP through cellular respiration, serving as the cell’s energy source. They also regulate metabolism, generate reactive oxygen species, and play roles in various cellular processes. Additionally, mitochondrial dysfunction is central to aging and age-related diseases, as it can lead to cellular energy deficits and contribute to the development of age-related health conditions.

Mitochondrial dysfunction

refers to any condition that disrupts the normal function of mitochondria. Various factors, including genetic mutations, environmental toxins, infections, and age-related changes, can cause mitochondrial dysfunction. Some common symptoms of mitochondrial dysfunction include muscle weakness, fatigue, cognitive impairment, and neurological disorders such as Parkinson’s and Alzheimer’s disease.

Mitochondrial dysfunction can also contribute to a wide range of other health conditions, including diabetes, cardiovascular disease, and cancer. Treatment options for mitochondrial dysfunction depend on the underlying cause of the condition and may include lifestyle changes, dietary modifications, medications, and other therapies.

Mitophagy

is a cellular process that selectively removes damaged mitochondria. It prevents the buildup of toxic molecules and contributes to cellular health. Dysfunctional mitophagy is associated with diseases like neurodegenerative disorders, cancer, and metabolic disorders.

We identified novel compounds that are strong Mitophagy Inducing Compounds (MIC)

These compounds may have a significant role on disease and aging.